GPT and fungal infectious disease: There are recommendations to avoid TZB in patients with immunosuppression, alanine aminotransferase levels greater than five times the upper normal limit, in patients with high risk for gastrointestinal perforation, in serious bacterial or fungal infections, in patients with an absolute neutrophil count <500 cells/μl, platelet count <50.000 cells/μl, or known hypersensitivity (38).