More importantly, atherosclerosis indices for the eNOS ‘constitutively active (S1176D; Akt1−/−; ApoE−/−)’ group herein are all less than what we previously reported for the eNOS+/+; Akt1−/−; ApoE−/− DKO comparison group (13). The gene discussed is APOE; the disease is atherosclerosis.