The RyR2 is a receptor that is based on the sarcoplasmic/endoplasmic reticulum membrane [17] and controls the large release of Ca2+ from intracellular stores through cardiac systole [18].CPVT is a hereditary disease, due to a malfunction in Ca2+ ion transport or release from their storage in cardiac myocytes causing delay upon depolarization [14,16]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.