Consequently, this study was conducted to explore the association between SUA levels, serum oxido-inflammatory biomarkers, such as tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA), and the risk of CAD among patients with T2DM as the primary outcome. This evidence concerns the gene IL6 and coronary artery disorder.