Oncogenic signaling pathways have been demonstrated to induce ACLY‐dependent synthesis and utilization of acetyl‐CoA in malignancies, and empirical evidence substantiates the existence of a positive correlation between global histone acetylation levels and phosphorylated AKT at Ser473 (pAKT–S473) in gliomas and prostate cancers.20 The gene discussed is ACLY; the disease is Familial prostate cancer.