In specific cancer types such as breast and colon cancer, the knockdown of OGT engenders a significant diminution in H3K27me3 levels and in the protein stability of Enhancer of Zeste Homolog 2 (EZH2), without influencing the concentrations of H3K27 demethylases, UTX, and JMJD3.84 Here, EZH2 is linked to colonic neoplasm.