Specific gene deletion of the upstream Hippo kinases in the liver, such as MST1 and MST2 [17] and LATS1 and LATS2 [18], or their scaffold proteins SAV1 [19] and MOB1A and MOB1B [20], could lead to decreased phosphorylation of yes-associated protein (YAP) and Tafazzin (TAZ), followed by their translocation into the nucleus, which then binds to TEA domain transcription factors (TEADs) or other transcription factors to trigger a series of proliferative and anti-apoptotic gene expression, causing hepatomegaly and liver cancer [16,18–20]. This evidence concerns the gene TAFAZZIN and liver cancer.