ANG and acute respiratory distress syndrome: With the understanding that the angiopoietin/Tie (Ang/Tie) family has an established role in vascular physiology in regulating angiogenesis, vascular permeability, and inflammatory responses, our data corroborate effectiveness and mode of action of the clinical approach of treating dysfunction of the lung vascular endothelium (lung edema) in ARDS patients with the transient expression of a therapeutic COMP-Ang1 mRNA-cLNP modality.