Compared with the control mice, the mRNA levels of enzymes such as cytochrome P450 family 11 Subfamily a member 1 (CYP11A1), 11β-hydroxylase (CYP11B1), aldosterone synthase (CYP11B2) and 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) were significantly lower in the adrenal of hyperuricemia mice. This evidence concerns the gene HSD3B1 and hyperuricemia.