The top five differentially expressed T2DM-PRGs related to prognosis were PTEN (targeted by 128 miRNAs), BRD4 (targeted by 118 miRNAs), HSP90AB1 (targeted by 103 miRNAs), VIM (targeted by 96 miRNAs), and PKN2 (targeted by 91 miRNAs). This evidence concerns the gene PKN2 and type 2 diabetes mellitus.