Type 1 diabetes mellitus (T1DM), which is characterized by β-cell destruction and an absolute deficiency of insulin secretion (12), may lead to the accumulation of advanced glycation receptors and products (13) and appear more likely to have reproductive disorders (14), manifested by polycystic ovary syndrome (PCOS) (15), irregular menses (16, 17), and subfertility (18, 19). This evidence concerns the gene INS and type 1 diabetes mellitus.