CHI has a heterogeneous genetic etiology, and pathogenic variants in ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A, HK1, and INSR genes have been identified to cause isolated, persistent CHI (2). This evidence concerns the gene GCK and congenital isolated hyperinsulinism.