TRIM72 and malignant colon neoplasm: In colon cancer and normal colon tissues, MG53 may be expressed and secreted by stromal cells instead of normal colon or colon cancer cells, and serum MG53 levels are negatively correlated with colon cancer stage and metastasis, suggesting that the low MG53 levels in the serum of patients with colon cancer may be due to local tissue lesions (26).