This evidence indicates that HIFs promote the stemness properties of Cancer Stem Cells and contribute to their maintenance in hypoxic niches (Yun and Lin, 2014; Vadde et al., 2017; Zhang et al., 2021), by expanding the subpopulation of cells positive for CD133 marker (Heddleston et al., 2010; Maeda et al., 2016) and increasing the expression of other stem cell markers such as Oct4 and Nanog (Lin et al., 2021b). The gene discussed is PROM1; the disease is cancer.