STC1, Stanniocalcin 1, it has been found to promote metastasis, lipid metabolism and cisplatin chemoresistance in ovarian cancer (Lin et al., 2022), STC1 is mainly involved in STAT3-mediated proliferation in breast cancer (Avalle et al., 2022) and STC1 expression is thought to play an important role in driving tumor immune resistance (Lin et al., 2021). This evidence concerns the gene STAT3 and breast cancer.