Hyperactivation of TERT promoter −124A in bladder cancer cells is caused by phosphorylation of TRIM28, mediated by the mTORC1 (mammalian target of rapamycin complex 1), which abrogates the TRIM28/TRIM24 interaction leading to displacement of the repressor and causing significant upregulation of TERT expression (Agarwal et al., 2021). The gene discussed is TERT; the disease is urinary bladder carcinoma.