In particular, the GABPA/B tetramer selectively binds and activates the mutant TERT promoter, thus inducing overexpression of the TERT gene in several tumour types, including glioblastoma, melanoma, hepatocellular carcinoma and bladder cancer (Figure 2), (Bell et al., 2015). The gene discussed is TERT; the disease is hepatocellular carcinoma.