TERT and hepatocellular carcinoma: Nucleotide changes in the TERT promoter are considered trunk mutations in liver carcinogenesis, being identified in a consistent fraction of dysplastic nodules and at increased frequency in hepatocellular carcinoma (Nault et al., 2013; Totoki et al., 2014; Takeda et al., 2020; Fredriksson et al., 2014; Nault et al., 2014).