TERT and hepatocellular carcinoma: Moreover, Ningarhari et al. (2021) reported that nucleotide variations in the TERT promoter were more frequent in the subtype of hepatocellular carcinoma characterized by short telomeres, well-moderate differentiation, and low levels of alpha-fetoprotein, rare vascular invasion, chromosomal stability and lower aggressiveness compared to non-mutated tumours.