The different behavior of HEY and PEO1 cells grown in an iron-rich environment is a main difference with He J et al. Indeed, they demonstrated that either iron supplementation, or treatment with ferroptosis inducers (i.e., erastin and RSL3), or the genetic manipulation of ferroptosis modulators (i.e., GPX4) are cytotoxic in all cancer cell types during the detachment from ECM (He et al., 2023). The gene discussed is GPX4; the disease is cancer.