In this regard, we and others have demonstrated that the activation of ferritinophagic process, i.e., the degradation of ferritin shell, mediated by nuclear co-activator 4 (NCOA4), and the consequent release of free iron into the cytosol, primarily contributes to ferroptosis occurrence in ovarian cancer cells (Ying et al., 2021; Battaglia et al., 2022). The gene discussed is NCOA4; the disease is ovarian cancer.