Interestingly, these cytopenic phenotypes have been modeled using zebrafish, where homozygous deletion of Gata2b leads to neutropenia (Gioacchino et al., 2021a; Avagyan et al., 2021), and loss of the intronic enhancer of Gata2a results in monocytopenia and neutropenia (Dobrzycki et al., 2020; Mahony et al., 2023), providing direct insights into the molecular effects of GATA2 mutation in blood lineage differentiation in the hematopoietic system. The gene discussed is GATA2; the disease is Decreased total neutrophil count.