Interestingly, these cytopenic phenotypes have been modeled using zebrafish, where homozygous deletion of Gata2b leads to neutropenia (Gioacchino et al., 2021a; Avagyan et al., 2021), and loss of the intronic enhancer of Gata2a results in monocytopenia and neutropenia (Dobrzycki et al., 2020; Mahony et al., 2023), providing direct insights into the molecular effects of GATA2 mutation in blood lineage differentiation in the hematopoietic system. Here, GATA2 is linked to Decreased total monocyte count.