Different studies have also shown that tumor-derived exosomes can facilitate angiogenesis through the transfer of different cargo molecules, such as miRNAs, that modulate the expression of vascular endothelial growth factor (VEGF) or Hypoxia-inducible Factor 1α (HIF-1α), which is an important regulator of VEGF [62, 63]. Here, VEGFA is linked to neoplasm.