BRCA2 and posterior cortical atrophy: This is supported by studies of ctDNA and matched metastatic tissue biopsies that revealed a strong concordance in several gene alterations, including AR gene amplification and inactivating mutations in tumor suppressor genes (e.g., TP53, PTEN, RB1, BRCA2) [53, 54], suggesting that ctDNA analyses may be useful for molecular stratification of PCa patients with metastatic disease for more precise prognostic and predictive purposes.