In support of this, clock genes were found to be associated with cell cycle control and activation of oncogenic pathways including phosphatidylinositol 3-kinase (PI3K)/protein kinase B alpha and Rat sarcoma/mitogen-activated protein kinase (MAPK).25,26 In addition, other studies have demonstrated an association between clock gene dysregulation and epithelial-mesenchymal transition (EMT),25 immune cell exhaustion,26 and cancer cell dissemination.27 These studies highlight the prognostic value of circadian clock gene expression in multiple cancer types. This evidence concerns the gene CLOCK and cancer.