WNK2 and cancer: In support of this, clock genes were found to be associated with cell cycle control and activation of oncogenic pathways including phosphatidylinositol 3-kinase (PI3K)/protein kinase B alpha and Rat sarcoma/mitogen-activated protein kinase (MAPK).25,26 In addition, other studies have demonstrated an association between clock gene dysregulation and epithelial-mesenchymal transition (EMT),25 immune cell exhaustion,26 and cancer cell dissemination.27 These studies highlight the prognostic value of circadian clock gene expression in multiple cancer types.