In further support of this, BMAL1 expression levels correlate inversely with c-Myc37,38 and BMAL1 mutation has been shown to upregulate c-Myc expression.39 In contrast, Cry mutation decreased c-Myc expression.39 Intriguingly, BMAL1 mutation was shown to drive Apc loss of heterozygosity to upregulate c-Myc and drive colorectal cancer progression.30 Altogether, these data reveal that clock control of the cell cycle is critical for limiting cell growth and maintaining genome stability. Here, BMAL1 is linked to colorectal cancer.