MYC and colorectal cancer: In further support of this, BMAL1 expression levels correlate inversely with c-Myc37,38 and BMAL1 mutation has been shown to upregulate c-Myc expression.39 In contrast, Cry mutation decreased c-Myc expression.39 Intriguingly, BMAL1 mutation was shown to drive Apc loss of heterozygosity to upregulate c-Myc and drive colorectal cancer progression.30 Altogether, these data reveal that clock control of the cell cycle is critical for limiting cell growth and maintaining genome stability.