When comparing 3 separate cohorts of prostate cancer patients, no consistent association between circadian gene SNPs and prostate cancer fatality was found.42 However, this same study identified an association between CRY1 SNPs rs7297614 and rs1921126 and increased risk of fatal disease in 2 out of the 3 cohorts analyzed.42 These SNPs are predicted to influence splicing, suggesting a probable connection between the circadian clock and prostate carcinogenesis through proliferative signaling. This evidence concerns the gene CLOCK and prostate cancer.