CML has been linked to cell signaling and a variety of biotic and abiotic stimuli (Zhang et al., 2014; Yuan et al., 2017), and EPF (epidermal patterning factor) has been correlated to regulate many aspects of plant growth and development (Lu et al., 2019). This evidence concerns the gene HSPE1 and chronic myelogenous leukemia, BCR-ABL1 positive.