SPEF2 and intrahepatic cholangiocarcinoma: Among these genes, nine were associated with gut microbiota that promotes ICC, including Veillonellaceae (TECPR2), Alistipes (TOP1MT and CAPZB), Enterobacteriales (KCNQ1), and Firmicutes (AMBP, NID2, CAB39, SPEF2, and FRMD4A).