In the genomic context of gut microbiota that inhibits ICC development, both REEP6 and MTTP exhibit a significant positive correlation with Infiltration Score, significantly promoting the infiltration of Mucosal-Associated Invariant T cells (MAIT), Macrophages, as well as Natural Killer (NK) cells, and Follicular Helper T (Tfh) cells in ICC tissues (Figure 7B). This evidence concerns the gene REEP6 and intrahepatic cholangiocarcinoma.