REEP6 and intrahepatic cholangiocarcinoma: Conversely, the remaining eight genes were linked to gut microbiota with inhibitory effects on ICC, including Anaerostipes (SOS1, PALLD, and REEP6), Paraprevotella (WWTR1), Parasutterella (CC2D2A), and Verrucomicrobia (CENPN, MTTP, and DST).