Conversely, the remaining eight genes were linked to gut microbiota with inhibitory effects on ICC, including Anaerostipes (SOS1, PALLD, and REEP6), Paraprevotella (WWTR1), Parasutterella (CC2D2A), and Verrucomicrobia (CENPN, MTTP, and DST). Here, DST is linked to intrahepatic cholangiocarcinoma.