In genes associated with gut microbiota that inhibit ICC, the expression of WWTR1, REEP6, CC2D2A, DST, and PALLD is positively correlated with sensitivity to AT-7519, Tubastatin A, AR-42, BHG712, BMS345541, BX-912, CAY10603, CP466722, GSK1070916, I-BET-762, JW-7-24-1, KIN001-260, Methotrexate, NG-25, NPK76-II-72-1, Navitoclax, PHA-793887, PIK-93, QL-XI-92, TG101348, THZ-2-102-1, TL-1-85, TPCA-1, Vorinostat, and XMD13-2, while it is negatively correlated with 17-AAG and Docetaxel. Here, REEP6 is linked to intrahepatic cholangiocarcinoma.