In genes associated with gut microbiota that promote ICC, we found a positive correlation between KCNQ1 expression and sensitivity to YM155, QL-VIII-58, and Docetaxel; CAB39 showed a negative correlation with AT-7519; AMBP displayed a positive correlation with YM155, QL-VIII-58, THZ-2-102-1, Docetaxel, ZG-10, and AT-7519, while it exhibited a negative correlation with Erlotinib, Lapatinib, EHT 1864, FH535, and Pazopanib; NID2 had a significant negative correlation with Docetaxel and Pazopanib; TECPR2 showed a negative correlation with QL-VIII-58, Docetaxel, and ZG-10. Here, TECPR2 is linked to intrahepatic cholangiocarcinoma.