Among these genes, nine were associated with gut microbiota that promotes ICC, including Veillonellaceae (TECPR2), Alistipes (TOP1MT and CAPZB), Enterobacteriales (KCNQ1), and Firmicutes (AMBP, NID2, CAB39, SPEF2, and FRMD4A). This evidence concerns the gene KCNQ1 and intrahepatic cholangiocarcinoma.