Therefore, the purposes of this study are to investigate the effect of locally administered CU gel after SRP in systemic inflammatory biomarkers levels and compared to Tetracycline gel in combination with SRP on the systemic inflammatory biomarkers of IL-6, MMP-8, CRP, ALP, and IL-10 in experimentally induced periodontitis (EP) in rats. The gene discussed is MMP8; the disease is periodontitis.