Similar to the current study, previous research has examined the impact of local application of Curcumin gel on decreasing serum levels of IL-6 and CRP in rats with experimentally induced periodontitis, and findings have shown that the Curcumin-treated group have lower levels of these biomarkers than those of the control group (Zhou et al., 2013; Gorabi et al., 2022). The gene discussed is CRP; the disease is periodontitis.