To explore the mechanism, we transfected the pEF1α-Myc-IFI6 recombinant plasmid and si274 against IFI6 into DF-1 cells, overexpressed or inhibited the expression of the IFI6 gene in these DF-1 cells, infected the cells with ARV 24 h after transfection, and collected infected cell samples 24 h after infection. The gene discussed is IFI6; the disease is infection.