ARV S1133 infection in specific-pathogen-free chickens can induce changes in the expression of various innate immunity-related factors, including IFN-α, IFN-β, IFN-γ, IL-6, IL-17, IL-18, MX, IFITM3, PKR, OAS, IFIT5, ISG12, VIPERIN, and IFI6, in chicken peripheral blood lymphocytes and joints (Xie et al., 2019; Wang et al., 2021, 2022). Here, IFI6 is linked to infection.