For example, IFI6 is highly expressed in gastric cancer cell lines and tissues, is enriched mainly in the inner mitochondrial membrane, colocalizes with cytochrome c in mitochondria, and can inhibit caspase-3 activity by inhibiting mitochondrial membrane depolarization and the release of cytochrome c, which results in the inhibition of apoptosis (Tahara et al., 2005). Here, CYCS is linked to gastric cancer.