The upregulated or downregulated expression of these factors was identified in comparison with the corresponding controls, which were different, and thus, the magnitude of the changes after overexpression or inhibition could not be compared to determine the involvement of IFI6 in the regulation of IRF7, TBK1, LGP2, IFN-α, and IFN-γ expression after infection with ARV. The gene discussed is TBK1; the disease is infection.