Linkage analysis, conducted on a genome-wide scale, has identified chromosome-12p as a region of interest for AD, encompassing LDL-receptor-related protein-1, α2-macrogobulin, and lectin-like ox-LDL receptor 1 (OLR-1) as a susceptible region for AD (Wu et al., 1998; Lee et al., 2008). The gene discussed is LRP1; the disease is Alzheimer disease.