For example, 4 weeks βHB therapy, in the C57BL/6 mice models of ApoE-deficient AD, which causes progressive p-tau Ser202/Thr205 accumulation, significantly ameliorated tau tangles colocalized in the hippocampal region of ApoE4 transgenic mice (Krishnan et al., 2020). The gene discussed is APOE; the disease is Alzheimer disease.