Increased number of intracellular p-tau in the amygdala, subiculum, CA1 and CA3 of the hippocampus in AD male 3xTgAD mice models has been modified followed by taking a ketone ester diet comprising of D-β-hydroxybutyrate and (R)-1,3-butanediol (Kashiwaya et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.