These abnormal glucose homeostasis in the brain (An et al., 2018) such as reduced uptake and utilization of brain glucose, perturbed glucose metabolism, reduced glycolysis and insulin and insulin-like growth factor-1 (IGF-1) resistance can cause a deficit in brain energy metabolism reported in AD brain (De La Monte, 2012; Szablewski, 2021). This evidence concerns the gene IGF1 and Alzheimer disease.