A total 19 lncRNAs were differentially expressed in osteosarcoma tissues (n=5) compared with paired normal tissues based on the GEO database (GSE126209) (|FC| > 1.0 and adj.p < 0.01) (Figure 1A), and 2 of them (PVT1 and PRR7-AS1) had a significant effect on the overall survival of OS patients (n=85) based on the TARGET database (Figure S1). This evidence concerns the gene PRR7 and osteosarcoma.