AHNAK and lung adenocarcinoma: Another study seemed to confirm the above results, stating that AHNAK expression was decreased in human lung adenocarcinoma, that AHANK-/- mice showed increased lung volume, alveolar wall thickening, and type II alveolar epithelial cell proliferation, and that approximately 20% of aged AHNAK-/- mice developed lung tumors and were more susceptible to lung cancer under urethane induction (48).