A decrease in pAkt, pS6, and p4EBP1 signals in the RA2 tumor nodule extracts 4 h after the last oral drug administration by gavage was observed (Figure 5D), proving that MEN1611 suppresses tumor growth in the xenograft model through inhibition of the PI3K/AKT pathway. The gene discussed is PIK3CB; the disease is neoplasm.