CD206 engages on macrophages maintaining the endocytosis and phagocytosis, and thus immune homeostasis by scavenging unwanted mannoglycoproteins; however, through their interactions with tumor mucins or upon an agonist anti-mannose receptor mAbs, they induced an immunosuppressive phenotype with increased production of cytokines such IL-10 by TAMs (74, 94). Here, MRC1 is linked to neoplasm.