STAT3 and neoplasm: Similarly, M2-polarized TAM-derived EVs showed an activity to influence proliferation, migration, invasion, and tumorigenesis of meningioma tumors through activation of TGF-β signaling, and with delivery of oncomiR-21 and AKT, STAT3, MTOR, and ACTB mRNA expression showed to support progression, migration, tumor sphere generation, and cisplatin resistance of bladder cancer (52, 90).