STAT3 and cancer: Whereas EMT and metastasis induction in a model of non-small cell lung cancer (NSCLC) were facilitated by upregulation of αβ-crystallin upon co-culture of TAMs with cancer cells (153), phosphorylated STAT3 with upregulation of cyclooxygenase-2 and MMP-9 led to EMT induction, invasion, and metastasis in animal models of osteosarcoma (154).