Furthermore, an altered-excluded tumor is characterized by TME infiltration of CD8+T cells located at the edge of the invasive margin of the tumor dominated by an abnormal vasculature (and consequent hypoxia) and a dense stroma, while altered-immunosuppressed tumors are characterized by the presence of a low degree of immune infiltration and an immunosuppressive, often hypoxic TME that limits further recruitment of immune cells and promotes an expansion of tumor (9, 10, 13–17). The gene discussed is CD8A; the disease is neoplasm.