TGFB1 and neoplasm: A protumorigenic TME is saturated with several supporting tumor growth cytokines like interleukin (IL)-4, IL-6, and IL-10 as well as transforming growth factor (TGF)-β, interferon (IFN)-γ, and chemokines such as chemokine (C-C motif) ligand 2 (CCL2) (3, 5, 7, 8, 12, 20, 21).