TRPC6 is highly expressed in PASMCs in patients with idiopathic pulmonary arterial hypertension (iPAH) and is involved in PASMC proliferation by initiating and promoting cell cycle growth, and by triggering gene transcription via transcription factor phosphorylation (Yu et al., 2004). The gene discussed is TRPC6; the disease is idiopathic pulmonary arterial hypertension.