In freshly isolated PAEC’s and PASMC’s from intrapulmonary artery rings in a rat model of chronic hypoxia-induced pulmonary hypertension, Yoda1, a Piezo1 agonist, was found to induce and activate the AKT-endothelial nitric oxide synthase (eNOS) pathway (Porto Ribeiro et al., 2022). This evidence concerns the gene NOS3 and pulmonary arterial hypertension.