Recently, several studies reported that overexpression of FXR in the kidney substantially alleviated hypertension and elevated renal nitric oxide (NO) levels, which was achieved by stimulating the expression of endothelial nitric oxide synthase (eNOS) in a mouse model of hypertension induced by an 8-week regimen of 20% fructose in drinking water combined with a 4% sodium chloride diet (referred to as HFS) (Ghebremariam et al., 2013; Li et al., 2015). Here, NOS3 is linked to hypertensive disorder.