Supported by CiteSpace software, 15 major clustering tags were formed based on cocited references, including bone mass, sclerostin antibody, osteogenic differentiation, multiple myeloma, genome-wide association studies, beta-catenin activation, tgf-beta signaling pathway, mesoderm formation, cartilage development, Wnt-5a inhibit, chondrocyte differentiation, hematopoietic stem cell, bmp9-induced osteogenic differentiation, peroxisome proliferator-actibated receptor gamma, extracellular signals cell interaction and pax6-dependent epidermal growth factor family (Figure 5B). This evidence concerns the gene GDF2 and plasma cell myeloma.