S1PR2 and meningococcal meningitis: This study demonstrates tight regulation of the S1PR2 and S1PR1+3 signaling on BECs disrupted during N. meningitidis infection by a novel criss-cross transactivation mechanism involving the three individual receptor systems CD147, S1PR2 and EGFR and illustrates the possible therapeutic potential of targeting this signaling cascade in meningococcal meningitis.