Several other pathways, including those involved in the hypoxia protective response and Wnt signalling, showed some preferential expression but did not reach formal statistical significance in our experiments, although the pathway ‘cell-cell signalling by wnt’ was identified in the analysis of GO Biological Pathways (R5) (see Supplementary Information), which links with findings of the wnt/beta-catenin pathway being involved in brain endothelial integrity in malaria [69]. This evidence concerns the gene CTNNB1 and malaria.