However, as NF-κB transcription factors regulate the expression of genes involved in several critical physiological processes, including cell survival, growth, proliferation, oxidative stress responses, inhibition of apoptosis, inflammation and immune responses, direct inhibition of NF-κB signaling can lead to immunodeficiency and dysregulation of the associated physiological activities [4, 5]. Here, NFKB1 is linked to Immunodeficiency.