Pooled analyses indicated statistically significant associations between the FTO rs8050136 polymorphism and increased risk of T2DM (P-value <0.05) under all genetic models (the dominant model (Fig 4A), AA+AC vs. CC: OR 1.2; the recessive model (Fig 4B), AA vs. AC+CC: OR 1.2; the AA vs. AC model (Fig 4C): OR 1.13; the AC vs. CC model (4d): OR 1.13; the AA vs. CC model (Fig 4E): OR 1.3; allele contrast, A vs. C (Fig 4F): OR 1.13 and the overdominant model (Fig 4G), OR 1.09 (Fig 4 and S4 Table). Here, FTO is linked to type 2 diabetes mellitus.