To test the effects of wild-type and mutant RBM10 on tumor growth in a more physiological context, we inoculated the p53-deficient H1299 cells into SCID mice after the cells were infected with lentivirus that expressed either wild-type RBM10 or RBM10-I316F (SI Appendix, Fig. S12 A–D). Here, TP53 is linked to neoplasm.