TP53 and lung carcinoma: In our attempt to address the p53-independent tumor suppression function of RBM10, we found that RBM10 can decrease the protein level of c-Myc, as overexpression of RBM10 led to the drastic decrease of c-Myc protein levels in p53-deficient colorectal cancer HCT116 (Fig. 1A) and lung cancer H1299 cells (SI Appendix, Fig. S3A).