In this sense, it is reasonable to infer that those polymorphic changes could also affect the prognosis of patients with COVID-19, with the D allele of ACE, associated with increased enzyme activity, and the ACE2 G allele, associated with decreased enzyme activity, prone to deleterious effects in the organisms, as previously shown in a study of our research group related to hypertension susceptibility [22]. This evidence concerns the gene ACE and COVID-19.