ACE2 and COVID-19: The initial results of non-association for ACE and ACE2 polymorphisms analyzed separately are in agreement with a case study conducted by Karakaş Çelik et al. (2021) [32] that evaluated 155 patients divided into three COVID-19 groups (mild, moderate, and severe); however, the referred research has not explored the genotypic combination analyses, which have brought interesting association findings to this work and have been an important tool to be employed on genetic association studies [22].