ACE and COVID-19: However, it was found that the genotypic combination of the II genotype of ACE with the A allele of ACE2 (II/A_) was significantly more frequent in female individuals from the mild outcome group of COVID-19 (χ2 = 4.83; p = 0.028), presenting a protective role against the worsening of the disease (ORA = 0.26; p = 0.037).