The synergistic effects of ACE and ACE2 are in accordance with their counterbalancing biological roles in RAS and constitute a finding that has already been highlighted in another study of our research group [22], which revealed an important association of the DD/G_ profile with hypertension susceptibility (ORA = 3.57; p = 0.026), comorbidity, which is also a COVID-19 risk factor. This evidence concerns the gene ACE and COVID-19.