Thus, among the decreased genes were WD repeat domain 46 (WDR46), which has been associated with diabetic retinopathy (19), integrin subunit α2 (ITGA2), which has been associated with T2D and its complications (20), and matrix metalloproteinase 11 (MMP11), which protects against T2D in mice (21), all of which showed 50%–70% decreases in cells from the I-Res donors (Figure 1D). Here, WDR46 is linked to type 2 diabetes mellitus.