In addition, an almost equal fraction of nondiabetic people within the general population have been shown to have a level of insulin resistance similar to that of patients with T2D when assessed by levels of circulating insulin, homeostatic model assessment for insulin resistance (HOMA-IR), euglycemic clamp, or steady-state plasma glucose in response to a fixed insulin and glucose infusion (5, 6). The gene discussed is INS; the disease is type 2 diabetes mellitus.