In contrast, we found decreased expression of genes associated with cell adhesion (such as ITGA2), axon guidance (including WNT3), and calcium ion–dependent exocytosis, as well as TONSL, a negative regulator of NF-κB–mediated transcription, all of which have been linked to T2D through SNPs (48). This evidence concerns the gene ITGA2 and type 2 diabetes mellitus.