PRPH2 and type 2 diabetes mellitus: Some representative examples of genes increased in expression in I-Res cells included peripherin 2 (PRPH2), which is associated with inherited retinal dystrophy (22), the secretin receptor (SCTR), which has a GWAS risk allele for development of T2D (23), and GATA5, a transcription factor involved in multiple processes, including pancreatic development (24), all of which exhibited 2- to 3-fold increases in cells from I-Res donors.