iPSCs were created from 20 individuals without diabetes, half in the top quintile of insulin sensitivity (I-Sen) and half in the bottom quintile of insulin sensitivity, i.e., most insulin resistant (I-Res), previously identified by population screening using the steady-state plasma glucose (SSPG) approach (17); the iPSCs were derived from blood cells using nonintegrative Sendai virus (18). This evidence concerns the gene INS and diabetes mellitus.