TNNI3 and Myocardial fibrosis: Compared to males, females had higher LVEF (median 43% vs 39%, P = 0.02), smaller indexed left ventricular volumes (left ventricular end-diastolic volume index: 112 mL/m2 vs 120 mL/m2; P < 0.001), less commonly had myocardial fibrosis (23% vs 42%), and lower concentrations of hs-cTnI (5 vs 6.7 ng/L, P < 0.001) (Table 1) with no difference in age at study enrollment, guideline-directed HF medication use (guideline-directed medical therapy [GDMT]), NT-proBNP concentrations, or extent of myocardial fibrosis.