While identifying novel Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors for malaria, Alzain et al. [1] downloaded the crystal structure of the protein using PDB ID 7KZ4 and prepared it for docking by creating disulfide bonds, adding hydrogens, removing water beyond 5 Å from hetero groups, creating zero-order metal bonds, and creating het states with Epik to ensure PfDHODH had the ideal structural orientation for docking. This evidence concerns the gene DHODH and malaria.