When HPV infects the larynx, for example, it can cause overexpression of the proto-oncogene Ras-like protein (RAS) or gene mutation, as well as failure of cell membrane signal transduction mediated by protein product P21, which can lead to malignant cell proliferation and laryngeal cancer (Yang et al. 2019a). This evidence concerns the gene CDKN1A and laryngeal carcinoma.