MGMT and neoplasm: Recent guidelines, such as the European Association for Neuro-Oncology (EANO) guideline, recommended to treat IDH-wildtype glioblastoma patients ≥ 70 years with surgery followed by hypofractionated radiotherapy for MGMT-promoter-unmethylated tumours and followed by the standard concomitant and adjuvant radiotherapy with temozolomide or temozolomide alone [6].