In a mouse model of CRC (n = 36), oral administration of the probiotics Lcr35 (Lactobacillus casei variety rhamnosus) and LaBi (Lactobacillus acidophilus and Bifidobacterium bifidum) improved chemotherapy-induced (5-fluorouracil) intestinal mucositis and suppressed upregulation of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 [173]. The gene discussed is TNF; the disease is colorectal carcinoma.