Similarly, Liu et al. conducted study showing that Lactobacillus fermentum ZS40 reduced cancer burden and inflammation in AOM/DSS-induced CRC mouse models by suppressing the expression of inflammatory cytokines TNF-α and IL-1β, as well as key proteins IκBα and p65 in the NF-κB signal pathway [187]. This evidence concerns the gene TNF and colorectal carcinoma.