NK cells in HBV_HCC were notable, they exhibited the highest active to stemness ratio (highest CD69:TCF-7 or CD25: TCF-7), the most severe exhaustion (highest PD-1/TIM-3/TOX expression), and low cytotoxicity (GZMB expression was inhibited) (Fig. 2A). Here, PDCD1 is linked to hepatocellular carcinoma.