CD4 and hepatocellular carcinoma: In addition, TCF-7 expression was driven by disease types, HBsAg_low/HCC/NAFL enhanced TCF-7 expression on CD4+/CD8+ T cells, whereas Acute/AFL_HCC/Chronic/Cirrhosis/HBsAg_high/NAFL_HCC suppressed it (Fig. 4A and C).