The effect of different lesions on the effector phenotype of CD4+/CD8+ T cells was not completely consistent (Fig. 4B and D), Acute/AFL_HCC/Chronic/Cirrhosis/HBsAg_high/HCC/NAFL_HCC were seen to inhibit effector CD4+/CD8+ T cells, and NAFL inhibited effector CD8+ T cells (Fig. 4B and D). Here, CD8A is linked to hepatocellular carcinoma.