CD4 and hepatocellular carcinoma: We found that HBV_HCC was a distinct HCC, and the expression of GZMB on infiltrating CD4+/CD8+ T cells was increased instead, which was consistent with HBsAg_low (GZMB expression was upregulated in HBsAg_low and downregulated in HBsAg_high) (Fig. 4A and C).