Previously, we first showed that TB was correlated with lymph node metastasis and EMT in HNSCC and then uncovered that the decrease of miR‐320a enhanced aggressiveness of TB cells by targeting SUZ12.[2, 6] In the current study, we extended our findings to characterize the dynamic transcriptomic signatures of TB in HNSCC during the metastasis cascades. This evidence concerns the gene SUZ12 and tuberculosis.