Recently, it has been implicated that the formation of phase separation is critical for the SE‐driven gene transcription, which can guarantee the highly concentrated transcriptional machinery at regions of SEs to activate the expression of cell identity genes.[10] Interestingly, our FISH and IF experiments revealed that the distribution of CYTOR and FOSL1 was not even throughout the nucleus, but instead formed puncta in HNSCC cells, which is a feature of phase‐separated like condensates. Here, FOSL1 is linked to head and neck squamous cell carcinoma.