Previously, we first showed that TB was correlated with lymph node metastasis and EMT in HNSCC and then uncovered that the decrease of miR‐320a enhanced aggressiveness of TB cells by targeting SUZ12.[2, 6] In the current study, we extended our findings to characterize the dynamic transcriptomic signatures of TB in HNSCC during the metastasis cascades. Here, SUZ12 is linked to head and neck squamous cell carcinoma.