Previously, we have shown that FOSL1 is a master regulator that promotes the malignant progression of HNSCC via establishing SEs.[9] To investigate the potential roles of CYTOR in establishing FOSL1‐dependent SEs (FOSL1‐SEs), we characterized FOSL1‐SEs using the FOSL1‐ChIP signals. The gene discussed is FOSL1; the disease is head and neck squamous cell carcinoma.