By combining the four readouts, ICAM1, ROS, VE‐cadherin and nuclei counts (cell death), we generated two ranked lists: the “pro‐endothelial dysfunction (pro‐ED)” list includes 26 genes that when knocked down significantly exacerbate the ED phenotypes tested (Fig 2F), with TRAF1, FOS, HGF, SLC75A and NR4A2 being the top hits. The gene discussed is NR4A2; the disease is endothelial dysfunction.