In brief, extensive studies regarding the mechanistic effects of curcumin in CRC have underlined that apoptosis and cell cycle arrest are the main events mediating the compound’s anticancer properties while its effects on pyroptosis, inflammatory cell death, which involves inflammasome activation and maturation of proinflammatory cytokines, IL-1β and IL-18, remained elusive [41]. The gene discussed is IL18; the disease is colorectal carcinoma.