RREB1 and melanoma: Conventional melanoma FISH probes targeting RREB-1 (6p25) (ras responsive element binding protein 1), CCND1 (11q13) (cyclin D1), MYB(6q23) (myeloblastosis proto-oncogene) provide important diagnostic information in many melanocytic tumors, while their sensitivity and the specificity in spitzoid lesions are low, necessitating the development of newer probe designs [8].