Data analysis from cBioPortal (www.cbioportal.org) revealed a significant correlation between increase in CRM1 gene mRNA expression and advanced tumor stage (pTNM stages IVa, IVb, IVc compared to stage I) and advanced histological grade (G2, G3 compared to G1) (p < 0.05) (Figure 6). Here, XPO1 is linked to neoplasm.