XPO1 and neoplasm: At the same time, increased intracellular expression level of CRM1 was significantly associated with advanced tumor stage (p < 0.001), increased tumor invasion (p < 0.001), diffuse lymph node involvement (p < 0.001), distant metastasis (p = 0.026), vascular (p = 0.035) and perineural invasion (p = 0.008).