CRM1 is the solo nuclear transporter of many proteins with prognostic value in laryngeal cancer, such as P53, P16, P63, Rb, PTEN, Nuclear factor kappa B (NFκB), EGFR, Cyclin D1, Survivin, and BCL-2 [9,19,46,47]. This evidence concerns the gene RB1 and laryngeal carcinoma.