CRM1 is the solo nuclear transporter of many proteins with prognostic value in laryngeal cancer, such as P53, P16, P63, Rb, PTEN, Nuclear factor kappa B (NFκB), EGFR, Cyclin D1, Survivin, and BCL-2 [9,19,46,47]. The gene discussed is CCND1; the disease is laryngeal carcinoma.